Cell-free DNA in twin pregnancy: time to change screening recommendations
نویسندگان
چکیده
منابع مشابه
Prospective first-trimester screening for trisomies by cell-free DNA testing of maternal blood in twin pregnancy.
OBJECTIVES First, to examine in twin pregnancies the performance of first-trimester screening for fetal trisomies 21, 18 and 13 by cell-free (cf) DNA testing of maternal blood and, second, to compare twin and singleton pregnancies regarding the distribution of fetal fraction of cfDNA and rate of failure to obtain a result. METHODS This was a prospective study in 438 twin and 10 698 singleton ...
متن کاملPerformance of screening for aneuploidies by cell-free DNA analysis of maternal blood in twin pregnancies.
OBJECTIVES To report clinical implementation of cell-free DNA (cfDNA) analysis of maternal blood in screening for trisomies 21, 18 and 13 in twin pregnancies and examine variables that could influence the failure rate of the test. METHODS cfDNA testing was performed in 515 twin pregnancies at 10-28 weeks' gestation. The failure rate of the test to provide results was compared with that in 184...
متن کاملFetal RHD Genotyping Using Real-Time Polymerase Chain Reaction Analysis of Cell-Free Fetal DNA in Pregnancy of RhD Negative Women in South of Iran
Objective Maternal-fetal RhD antigen incompatibility causes approximately 50% of clinically significant alloimmunization cases. The routine use of prophylactic anti-D immunoglobulin has dramatically reduced hemolytic disease of the fetus and newborn. Recently, fetal RHD genotyping in RhD negative pregnant women has been suggested for appropriate use of anti-D immunoglobulin antenatal prophylaxi...
متن کاملchimeric external control to quantify cell free dna in plasma samples by real time pcr
background: dna isolation procedure can significantly influence the quantification of dna by real time pcr specially when cell free dna (cfdna) is the subject. to assess the extraction efficiency, linearity of the extraction yield, presence of co-purified inhibitors and to avoid problems with fragment size relevant to cfdna, development of appropriate external dna control (edc) is challenging. ...
متن کاملPrenatal aneuploidy screening using cell-free DNA.
REFERENCES 1. Hammers AL, Sanchez-Ramos L, Kaunitz AM. Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis. Am J Obstet Gynecol 2015;212:505.e1-13. 2. Ment LR, Ådén U, Lin A, et al. Gene-environment interactions in severe intraventricular hemorrhage of pret...
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ژورنال
عنوان ژورنال: American Journal of Obstetrics and Gynecology
سال: 2021
ISSN: 0002-9378
DOI: 10.1016/j.ajog.2021.02.024